Researchers at Kyoto University have published new data on cardiology.

"Organocatalytic regioselective acylation of digitoxin has been developed," scientists in Kyoto, Japan report (see also Cardiology).

"This method provides the 4'''-O-manoacylate as the sole product without the concomitant formation of diacylates," wrote K. Yoshida and colleagues, Kyoto University.

The researchers concluded: "The extremely high regioselectivity was assumed to be the result from the combined effects of the high intrinsic reactivity of C(4''')-OH and catalyst-promoted regioselective acylation of the same hydroxy group."

Yoshida and colleagues published their study in Tetrahedron Letters (Perfectly …